Research and Studies on Dihydromyricetin (DHM)

Unlike other products the market which use very few ingredients shown to have any impact on hangovers and alcohol intoxication, Dihydromyricetin’s benefits are backed by a large weight of research.

Countless studies have been performed on DHM, and they provide scientific evidence backing up claims that Dihydromyricetin:

  • Prevents hangovers
  • Prevents drunkenness, and reduces existing drunkenness.
  • Reduces symptoms of alcohol withdrawal.
  • Prevents and helps repair liver damage.
  • Can help prevent brain damage due to oxidative stress.
  • May inhibit growth and slow spread of certain types of tumors.

Dihydromyricetin and Alcohol

1. Dihydromyricetin as a novel anti-alcohol intoxication medication.

Conclusions:

• DHM is safe, and does not cause intoxication, sedation, or any other negative side effects when taken at normal doses

• Hovenia extracts (Dihydromyricetin) ameliorate alcohol-induced liver injuries (Du et al., 2010), and relieve hangover, partly by promoting EtOH elimination via enhancement of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH) activity. Acetaldehyde dehydrogenase is an enzyme responsible for breaking down acetaldehyde, a highly toxic chemical and one of the main causes of hangovers.

• DHM counteracts alcohol intoxication.

• Dihydromyricetin reduces alcohol withdrawal symptoms.

• DHM reduces voluntary alcohol consumption in rats.

Read Full Study

2. Influence of Hovenia dulcis DHM on alcohol concentration in blood and activity of alcohol dehydrogenase (ADH) of animals after drinking

Conclusions:

• Dihydromyricetin reduces existing intoxication and prevents drunkenness.

• DHM reduces Blood Alcohol Content (BAC)

• DHM reduces the amount of alcohol absorbed into the GI-tract.

• DHM improves the ability of the liver to metabolize alcohol and acetaldehyde. Acetaldehyde is produced when the body breaks down alcohol and is one of the main causes of hangovers.

Read Abstract

3. Pharmacological potential of ampelopsin (DHM) in Rattan tea

Conclusions:

• Significantly reduces ethanol-induced inebriation.

• Reduces cancer risks

• Hepaprotective: prevents and helps repair liver damage.

• Neuroprotective: prevents and helps repair damage to brain cells. While no experiments have been done to test DHM’s protective effect against damage to dendrites caused by chronic alcohol consumption, it’s neuroprotective properties suggest it could protect against such damage.

Read Full Study

4. Effects of fruits of Hovenia dulcis (DHM) Thunb on acute alcohol toxicity in mice

Conclusions:

• DHM reduces BAC and alcohol toxicity.

Read Abstract

Dihydromyricetin and Liver Damage

5. Effect of juice and fermented vinegar from Hovenia dulcis peduncles on chronically alcohol-induced liver damage in mice.

Conclusions:

• DHM (hovenia dulcis extract) has a significant protective effect against alcohol-induced liver damage.

Read Abstract

6. Treatment of Chronic Liver Injuries in Mice by Oral Administration of Ethanolic Extract of the Fruit of Hovenia dulcis

Conclusions:

• Hovenia dulcis extract (DHM) reduces injuries caused to the liver.

Read Abstract

7. Inhibitory effects of hovenia dulcis extract (ampelopsin) on angiogenesis

Conclusions:

• This study found an inhibitory effect of ampelopsin (DHM) on the growth of human hepatocellular carcinoma Bel-7402, which suggests it may help to prevent malignant hepatocellular carcinoma, the most common form of liver cancer.

Read Abstract

8. Hepatoprotective activity of tocha, the stems and leaves of Ampelopsis grossedentata, and ampelopsin.

Conclusions:

• Dihydromyricetin prevents liver damage caused by oxidative stress.

Read Abstract

9. Hepatoprotective effect of Hovenia dulcis Thunb. on experimental liver injuries induced by carbon tetrachloride or D- galactosamine/lipopolysaccharide

Conclusions:

• DHM showed significant hepatoprotective activity against CCl 4-toxicity in rats and D-galactosamine (D- GalN)/lipopolysaccharide-induced liver injury in mice.

• DHM significantly protected against CCl 4-toxicity in primary cultured rat hepatocytes.

Read Abstract

Dihydromyricetin and Cancer

10. Dihydromyricetin inhibits cell invasion and down-regulates MMP-2/-9 protein expression levels in human breast cancer cells

Conclusions:

DHM has an anti-proliferative effect in vitro on a few cancer cells

DHM can inhibit proliferation and invasion of MDA-MB-231 cells, and invasion inhibition may be related to the down-regulation of the expression levels of MMP-2/-9 proteins.

Read

11. Anti-tumor effects of ampelopsin (DHM) on human lung cancer GLC-82 implanted in nude mice

Conclusions:

• DHM inhibited growth and proliferation of human lung cancer tumors when implanted in mice.

Read Abstract

12. Study on inhibitory effect of ampelopsin (DHM) on melanoma by serologic pharmacological method.

Conclusions:

• DHM reduced the growth and profileration of B16 melanoma cells.

Read Abstract

13. Flavonoid Ampelopsin (DHM) Inhibits the Growth and Metastasis of Prostate Cancer In Vitro and in Mice

Conclusions:

• Dihydromyricetin reduces Prostate cancer risks

• DHM reduces the proliferation of existing prostate cancer cells

Read Full Paper

14. Anti-invasive and anti-metastatic effect of ampelopsin on melanoma

Conclusions:

• DHM reduced the invasion, migration, and adhesion of B16 melanoma cells in mice

Read Abstract

15. Ampelopsin sodium exhibits antitumor effects against bladder carcinoma in orthotopic xenograft models

Conclusions:

• DHM shows antitumor effects against bladder carcinoma

Read Abstract

Dihydromyricetin’s Neuroprotective Properties

16. Ampelopsin inhibits H2O2-induced apoptosis by ERK and Akt signaling pathways and up-regulation of heme oxygenase-1

Conclusions:

• DHM is a potent antioxidant

• DHM has neuroprotective properties

Read Abstract

The Research is Clear

Dihydromyricetin is an extremely effective supplement for preventing hangovers, reducing alcohol intoxication, and protecting your liver. As the other studies show it may also provide a number of other health benefits.

Experience firsthand the benefits that science has proven to be provided by Dihydromyricetin by giving it a try today. We offer a full money back guarantee, so there’s nothing to lose by giving it a try.